Stability studies of Pharmaceutical products
A presentation on stability studies at accelerated conditions is presented for formulated drug products briefly.
Polymorph in Drugs
Molecules exist in nature in any of the three states viz., solid. liquid and vapour. But most of the molecules, organic and inorganic , exist in solid states. It is very interesting that if these solid state molecules have therapeutic benefits, they’re used as a drug substance. In a solid state, the molecules or the elements exist as crystals which are oriented in a organised or disorganised ways. Hence multiple orientations are possible for a molecule. In a pharmaceutical drug, these different crystalline orientations are named as Polymorphs. Polymorphism may be defined as the ability of a compound to crystallize in two or more crystalline phases with different arrangements and/or conformations of the molecules in the crystal lattice. Hence, polymorphs are different crystalline forms of the same pure chemical compound. Since these crystalline forms are oriented differently, their free energies are also different which makes them as uniq...
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